Suppression of liver Apo E secretion leads to HDL /cholesterol immaturity in rats administered ethinylestradiol

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Suppression of liver Apo E secretion leads to HDL/cholesterol immaturity in rats administered ethinylestradiol

Ethinylestradiol (EE), a main component of the combined oral contraceptive pill, is associated with an increased risk of arterial diseases. However, the toxicity mechanism of EE is poorly understood. In this study, we found that the exposure to EE reduced the serum apolipoprotein E (Apo E) level and high-density lipoprotein (HDL)/cholesterol concentration in adult female rats. Diethylstilbestro...

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ژورنال

عنوان ژورنال: FEBS Open Bio

سال: 2016

ISSN: 2211-5463,2211-5463

DOI: 10.1002/2211-5463.12098